Man United and Man City both face significant tests in Week 11 of the 2017-18 English top tier as they take on Arsenal and Chelsea.
Pep Guardiola's Man City will look to continue their incredible winning streak to nine, and Jose Mourinho's Red's can down a second top-four rival in as many matches having beaten Spurs in their last game.
Tottenham, meanwhile, host Crystal Palace ahead of the two Manchester clubs' fixtures on Sunday, and Liverpool's visit to West Ham United is our pick of Saturday's encounters. Before we continue with our predictions and take a look at the pivotal players this week, you might want to check out some of the best betting apps that include betway and betwin.
Result predictions for Saturday, November 4th
Stoke City vs. Leicester City (1-0)
Huddersfield Town vs. West Bromwich Albion (1-2)
Newcastle Unites vs. Bournemouth (3-2)
Southampton vs. Burnley (0-1)
Swansea City vs. Brighton & Hove Albion (2-2)
West Ham United vs. Liverpool (1-1)
Predictions for Sunday, Nov. 5th
Tottenham Hotspur vs. Crystal Palace (3-0)
Man City vs. Arsenal (1-1)
Chelsea vs. Man United (0-0)
Everton vs. Watford (1-2)
David De Gea, Manchester United
Mourinho's strategy for matches against big clubs, especially away from home, rarely changes. He sets up his side not to concede and is happy to escape with a draw.
If the opposition makes a blunder and his gifted attackers take advantage to seize a win, then all the better. More crucial will be to maintain a clean sheet.
In Mourinho's first game back at his old club last season his ideas went out the window inside a minute, as the Spaniard Pedro scored after only 30 seconds before Chelsea eventually won 4-0. The Portuguese will not allow for the same to occur on Sunday.
Mourinho has now shown this season he has the players that can restrain bigger clubs, having drawn against Liverpool and beaten Tottenham 1-0.
Even with an excellent defensive performance, it looks highly unlikely that goalkeeper De Gea will not be tested at least once to keep out Chelsea's forward stars, which includes an in-form Eden Hazard.
Squawka Football, Eden Hazard's game by numbers vs. Bournemouth: 90% pass accuracy, seven chances created, two take-on, two crosses, two shots, one goal. Strong display.
Nicolas Otamendi, Man City
City's attacking exploits have been well documented already this season. Guardiola's men have been scoring for fun in 2017-18, returning 35 goals in 10 matches in the English top flight, with ten various players finding the back of the oppositions net.
There seems slight chance that their contenders at Sunday, Arsenal, will be capable of stopping them from scoring, especially as Man City are playing at a home soil.
However, the Gunners will likely take heart from some poor Sky blues defending in their 3-2 victory over West Brom last time out. It was a comfortable triumph over the Baggies in the end for Man City. Although, both goals they allowed were avoidable.
John Stones was canceled by a flighted Gareth Berry delivery for Jay Rodriguez's first goal, and later on, Otamendi gifted Matt Phillips the second in stoppage time after a mistimed chest back to his goalkeeper.
The Argentinian can't allow being so sloppy facing Arsenal offensive line that features the likes of Alexis Sanchez, Mesut Ozil, and Alexandre Lacazette. Both Otamendi and Stones will need to deliver top performances if City is to win on Sunday.
Mohamed Salah, Liverpool
Klopp's Liverpool have won only one of their five away Premier League games so far this term, and have conceded 15 times on the road. They travel to a struggling West Ham side on Saturday whose last game at the London Stadium ended in an embarrassing 2-0 defeat to Brighton.
The trip to east London should allow the Reds the perfect chance to change their away record, which is in severe contradiction to their exploits at Anfield.
Liverpool's defensive problem is obvious but so are their attacking strengths. It seems inevitable Wes Ham will get a goal on Saturday, but Liverpool should have more than enough quality to out-score the Hammers.
Liverpool's pivotal attacking presence so far this season has been Mohamed Salah. Egyptian netted five league goals and provided two assists since his summer arrival. His blistering pace and movements are too much for some of the best defenses, while he also brings his team-mates into action.
If Salah is on form on Saturday, Liverpool should be able to claim their second away win of the season.